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From there, it travels into your bloodstream, which then transports it across your entire body

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However, the barriers limited permeability and highly active efflux transporters make drug delivery to the CNS challenging 1

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Uptake of Na + in endothelial ion transporters through NaKCl cotransporter and Na/H exchanger that does not depend on ATP is not effectively counterbalanced by Na + secretion, leading to endothelial cell swelling and BBB breakdown ( + is promoted by a failing Ca 2+ -ATPase coupled with a functioning Na + /Ca 2+ exchanger with plenty of intracellular Na +